Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

71
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
71

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Efficacy of multipoint versus conventional biventricular pacing in CRT: systematic review and meta-analysis of randomized trials.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same journal

From inflammation to inheritance: rethinking myocarditis as the first signal of desmosomal cardiomyopathy.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same journal

Dynamic coronary roadmap-guided versus traditional percutaneous coronary intervention techniques in contrast medium volume reduction: a systematic review and meta-analysis.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same journal

Mid-aortic syndrome in two Saudi children with refractory hypertension: a case report.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same journal

Impact of cardiac amyloidosis on survival in aortic stenosis patients undergoing TAVR: a systematic review and reconstructed time-to-event meta-analysis.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same journal

Catheter ablation of typical atrial flutter in a patient with left ventricular assist device support: a case report.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026

Related Experiment Video

Updated: Sep 8, 2025

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

4.7K

Reperfusion injury in STEMI: a double-edged sword.

Krupa Sara Thomas1, Divina Mariya Puthooran2, Sudeep Edpuganti2

  • 1Department of Medicine, Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia. krupasara22@gmail.com.

The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology
|September 5, 2025
PubMed
Summary

Reperfusion injury after ST-elevation myocardial infarction (STEMI) worsens heart damage despite rapid treatment. New therapies targeting molecular pathways and AI are needed to improve patient outcomes and cardiac healing.

Keywords:
Artificial intelligenceCardioprotectionIschemia–reperfusion injuryMitochondrial dysfunctionNo-reflow phenomenonOxidative stressPrimary percutaneous coronary intervention (PPCI)Reperfusion injurySTEMI

More Related Videos

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography
09:23

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography

Published on: November 24, 2016

13.4K
Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice
08:28

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Published on: January 19, 2022

7.2K

Related Experiment Videos

Last Updated: Sep 8, 2025

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

4.7K
Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography
09:23

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography

Published on: November 24, 2016

13.4K
Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice
08:28

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Published on: January 19, 2022

7.2K

Area of Science:

  • Cardiology
  • Molecular Medicine
  • Biomedical Engineering

Background:

  • ST-elevation myocardial infarction (STEMI) necessitates prompt reperfusion, yet this process can paradoxically cause reperfusion injury, exacerbating cardiac damage.
  • Mechanisms of reperfusion injury include oxidative stress, calcium overload, mitochondrial dysfunction, and programmed cell death, leading to impaired myocardial healing and prognosis.

Purpose of the Study:

  • To conduct a comprehensive narrative review of reperfusion injury in STEMI, focusing on its pathophysiology, clinical impact, and emerging therapeutic strategies.
  • To highlight recent advancements in biomarkers, imaging, artificial intelligence, and treatment modalities for mitigating reperfusion injury.

Main Methods:

  • A narrative review of peer-reviewed literature from 2015-2025, sourced from ScienceDirect, PubMed, and Google Scholar.
  • Emphasis on molecular mechanisms, clinical manifestations (myocardial stunning, no-reflow), diagnostic tools (cardiac MRI, biomarkers), and therapeutic interventions (conditioning, pharmacological agents).

Main Results:

  • Reperfusion injury involves complex molecular pathways including reactive oxygen species, calcium dysregulation, and mitochondrial pore opening, contributing to adverse outcomes like heart failure.
  • Current diagnostic tools like cardiac MRI and biomarkers (NT-proBNP, sST2) aid risk stratification, but many promising therapies have shown inconsistent efficacy in clinical trials.
  • Mechanical conditioning techniques and pharmacological approaches are being investigated, alongside AI for risk assessment and early diagnosis.

Conclusions:

  • Reperfusion injury remains a significant barrier to optimal recovery post-STEMI, underscoring the need for adjuvant therapies beyond standard revascularization.
  • Future directions include molecular-targeted therapies, AI-driven precision medicine, and addressing sex-specific risk factors to reduce cardiac damage and improve long-term outcomes.