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Fabricating a UV-Vis and Raman Spectroscopy Immunoassay Platform
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Engineered Substrate-Free Small Molecules for Enhanced Raman Scattering and Photothermal Conversion Efficiency.

Sheng Yu1, Shuai Gao1, Yongming Zhang2

  • 1School of Pharmacy, Minhang Hospitial, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|September 5, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed BBTPPRO, a novel small molecule for ultrasensitive in vivo Raman imaging and photothermal therapy. This substrate-free approach enhances bioimaging precision and cancer treatment efficacy.

Keywords:
Raman scatteringin vivo Raman imagingmolecular engineeringphotothermal therapytheranostics

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Area of Science:

  • Biomedical Engineering
  • Molecular Imaging
  • Nanotechnology

Background:

  • Surface-enhanced Raman scattering (SERS) offers high-precision bioimaging but requires metal substrates.
  • Stacking-induced intermolecular charge transfer-enhanced Raman scattering (SICTERS) provides substrate-free, ultrasensitive in vivo Raman imaging.
  • Molecular engineering is needed to optimize SICTERS intensity and photothermal conversion efficiency for biomedical applications.

Purpose of the Study:

  • To design and synthesize an optimized small molecule (BBTPPRO) with enhanced SICTERS intensity and photothermal conversion efficiency.
  • To develop substrate-free Raman imaging agents for enhanced biomedical applications.
  • To demonstrate intraoperative Raman image-guided photothermal therapy (PTT).

Main Methods:

  • Molecular engineering of bis-thienyl-substituted benzobisthiadiazole by modifying side chains and introducing benzene rings.
  • Preparation of BBTPPRO nanoparticles.
  • Utilizing SICTERS principles and Jablonski diagram for molecular design.
  • In vivo testing for orthotopic mouse colon tumor imaging and PTT.

Main Results:

  • An optimized molecule, BBTPPRO, was synthesized, exhibiting high SICTERS intensity.
  • BBTPPRO demonstrated a significant photothermal conversion efficiency of 31.19%.
  • BBTPPRO nanoparticles enabled intraoperative Raman image-guided PTT in a mouse colon tumor model.

Conclusions:

  • A molecular strategy combining SICTERS and Jablonski diagram principles was successfully employed.
  • Substrate-free Raman small molecules were designed as potential SICTERS-mediated photo-theranostic agents.
  • BBTPPRO shows promise for advanced theranostic applications in oncology.