Related Experiment Video
Updated: May 11, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
UV-promoted surface-enhanced Raman spectroscopy via heterojunction of few-layer MoS2 flakes on acceptor-rich β-Ga2O3
Wenjing Jia1,2, Yinzhou Yan1,2, Yao Yao1,2
1School of Physics and Optoelectronic Engineering, Beijing University of Technology, Beijing, 100124, China.
Abstract:
Surface-enhanced Raman spectroscopy (SERS) by 2D semiconductors relies on chemical (CM) enhancement driven by charge-transfer (CT) processes in bandgap alignment between molecules and substrates. Unfortunately, the low light absorption and weak conferment in the atomic-layer material limit the enhancement factor of Raman intensity (EFRI). Improving the utilization efficiency of excitation light is therefore essential for promoting SERS performance of 2D semiconductors. Here we develop a heterojunction SERS substrate, composed of few-layer MoS2 (FL-MoS2) flakes capping onto the acceptor-rich β-Ga2O3 microstrips grown by optical vapor supersaturated precipitation (OVSP). The acceptor-rich β-Ga2O3 microstrips excited by ultraviolet (UV) irradiation boost the CT processes between FL-MoS2 and analyte molecules, by which the EFRI was increased by two orders of magnitude up to 9.33 × 10⁴ with the limit of detection (LoD) down to 10⁻9 M for methylene blue (MB). The in-situ experiment unveils that the SERS improvement is originated from the photoinduced carries trapped by the deep acceptor of Ga2- vacancies ([Formula: see text]) at 2.53 eV below conduction band minimum to facilitate the CT resonance. The present work provides new insights into the role of defect states in the chemical SERS mechanism, demonstrating the improvement of 2D-material substrate performance for ultrasensitive Raman detection.
More Related Videos
Related Concept Videos
UV–Vis Spectroscopy of Conjugated Systems
One of the factors influencing λmax is the extent of conjugation in the...
Molecular Spectroscopy: Absorption and Emission
UV–Vis Spectroscopy: Molecular Electronic Transitions
UV–Vis Spectrometers
Raman Spectroscopy: Overview
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Raman Spectroscopy Instrumentation: Overview
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

