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Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Related Experiment Video

Updated: Jun 28, 2026

Experimental Models for Study of Retinal Pigment Epithelial Physiology and Pathophysiology
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Bilateral multiple retinal pigment epithelial detachments.

Arisa Yoshida1, Masayuki Shibuya1, Yoshiaki Shimada1,2

  • 1Department of Ophthalmology, Saitama Medical University Faculty of Medicine, 38 Moro-Hongo Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Documenta Ophthalmologica. Advances in Ophthalmology
|September 5, 2025
PubMed
Summary

This case study tracks bilateral idiopathic multifocal retinal pigment epithelial detachments (imfPEDs) over 16 years, showing slow changes and preserved vision. Findings suggest imfPEDs may be a variant of large colloid or cuticular drusen.

Keywords:
Bilateral retinal pigment epithelial detachmentsCuticular drusenLarge colloid drusenMultifocal retinal pigment epithelial detachments

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Imaging

Background:

  • Bilateral idiopathic multifocal retinal pigment epithelial detachments (imfPEDs) are rare.
  • Long-term data on imfPEDs progression and functional changes are limited.

Purpose of the Study:

  • To document a rare case of bilateral imfPEDs.
  • To describe 16-year morphological and functional changes.
  • To assess diagnostic value of multimodal imaging and electrophysiology.

Main Methods:

  • Multimodal imaging (OCT, FA, FAF, fundus photography) was used.
  • Electrophysiological testing (ffERGs, mfERGs) assessed retinal function.
  • A 49-year-old female patient was followed for 16 years.

Main Results:

  • Initial diagnosis of bilateral PEDs confirmed.
  • Over 16 years, PEDs evolved with some resolving and new ones appearing.
  • Geographic atrophy noted peripherally; ffERGs normal, mfERGs showed localized attenuation.

Conclusions:

  • Bilateral imfPEDs exhibit slow morphological progression and relative functional preservation over 16 years.
  • Multimodal imaging and electrophysiology are key for monitoring imfPEDs.
  • The phenotype aligns with large colloid or cuticular drusen variants.