Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiac Output01:17

Exercise and Cardiac Output

1.3K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
1.3K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

21
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
21
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

798
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
798
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

1.2K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
1.2K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

1.5K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.5K
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

716
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
716

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model.

Experimental physiology·2026
Same author

Substrate-specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts.

Experimental physiology·2026
Same author

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients.

Experimental physiology·2026
Same author

Type 2 diabetes disrupts T-tubule and RyR2 organization in male but not in female rat ventricular muscle.

American journal of physiology. Heart and circulatory physiology·2026
Same author

The Absence of Collagen VI Reduces Systolic Function but Paradoxically Increases Ca<sup>2+</sup> Release in the Rat Heart.

Acta physiologica (Oxford, England)·2025
Same author

Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart.

Experimental physiology·2025
Same journal

Glutamatergic modulation of transcranial direct current stimulation over the premotor cortex combined with peripheral nerve stimulation promotes observation-execution-related cortical excitability and motor performance.

The Journal of physiology·2026
Same journal

The ultrarapid delayed rectifier potassium current has important functional role in the repolarization reserve of canine and human ventricular muscle.

The Journal of physiology·2026
Same journal

Tonotopically distinct OFF responses arise in the mouse auditory midbrain following sideband suppression.

The Journal of physiology·2026
Same journal

The multicellular environment of the re-entrant circuit in post-myocardial infarction ventricular tachycardia: Beyond fibrosis.

The Journal of physiology·2026
Same journal

Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.

The Journal of physiology·2026
Same journal

Longitudinal and cross-sectional evidence that daily resting and activity energy expenditures are independent in humans.

The Journal of physiology·2026
See all related articles

Related Experiment Video

Updated: Sep 8, 2025

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.6K

Danicamtiv increases cardiac mechanical efficiency.

Trent Meehan1, Toan Pham1, Kenneth Tran1

  • 1Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.

The Journal of Physiology
|September 5, 2025
PubMed
Summary
This summary is machine-generated.

Danicamtiv, a cardiac myosin activator, enhances heart muscle efficiency by increasing force output and work done without increasing energy use for calcium cycling. This study reveals its dual benefit for cardiac mechanics and energetics.

Keywords:
cardiac energeticscross‐bridge efficiencyheatmyosin activatorwork‐loop contraction

More Related Videos

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

8.4K
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.3K

Related Experiment Videos

Last Updated: Sep 8, 2025

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.6K
Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

8.4K
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.3K

Area of Science:

  • Cardiovascular Physiology
  • Biophysics of Muscle Contraction
  • Cardiac Energetics

Background:

  • Danicamtiv is a novel cardiac-specific myosin activator.
  • It is under investigation in pre-clinical and clinical trials for improving cardiac function.

Purpose of the Study:

  • To assess the effects of danicamtiv on cardiac energetics.
  • To elucidate the mechanisms behind danicamtiv's impact on myocardial force and efficiency.

Main Methods:

  • Isolated rat ventricular trabeculae were used for in vitro studies.
  • Muscle heat output was measured during isometric and work-loop contractions.
  • Trabeculae were exposed to danicamtiv (5 µM) to quantify its effects on force, heat production, and efficiency.

Main Results:

  • Danicamtiv increased twitch force, muscle heat, and cross-bridge heat.
  • It slowed isometric twitch and shortening kinetics.
  • Mechanical efficiency was enhanced due to a greater increase in work output than heat production, with no effect on Ca2+ cycling energy.

Conclusions:

  • Danicamtiv improves cardiac mechanical efficiency by optimizing the relationship between force generation and energy expenditure.
  • Its mechanism involves enhancing actomyosin interactions without increasing the energetic cost of calcium handling.
  • Danicamtiv shows promise as an inotropic agent with both mechanical and energetic benefits for the heart.