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Updated: Sep 8, 2025

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology
Published on: April 23, 2019
It must have been network (percolation for the synaptic function)
Julia Barczuk1, Dragomir Milovanovic2
1Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany; Medical University of Łódź, 90-419 Łódź, Poland.
Abstract:
How does synaptic wiring depend on receptor clustering, scaffold networks, and signaling cohorts? In a recent study in Molecular Cell, Jia et al.1 demonstrate that targeting the interaction strength between the scaffold proteins, rather than the total amount of each protein component, modulates the signal propagation across the protein network.
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