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Effect of henagliflozin on aging biomarkers in patients with type 2 diabetes: A multicenter, randomized,

Jie Zhang¹, Wei Cai², Danfeng Liu²

¹Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China; Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, Jiangxi 330006, People's Republic of China; Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, Jiangxi 330006, People's Republic of China.

Cell Reports. Medicine

|September 5, 2025

Summary

This summary is machine-generated.

Henagliflozin, a sodium-glucose cotransporter-2 inhibitor, significantly increased telomere length and improved glucose metabolism in a 26-week trial. This suggests potential anti-aging benefits by influencing key aging biomarkers.

Keywords:

aging clinical trial henagliflozin metabolomics sodium-glucose cotransporter-2 inhibitors type 2 diabetes mellitus

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Area of Science:

Endocrinology and Metabolism
Aging Research
Immunology

Background:

Sodium-glucose cotransporter-2 (SGLT2) inhibitors are explored as caloric restriction mimetics.
Limited clinical data exist on SGLT2 inhibitors' impact on aging biomarkers.

Purpose of the Study:

To evaluate the effects of henagliflozin on aging biomarkers in individuals with type 2 diabetes.
To investigate henagliflozin's influence on telomere length, metabolic markers, and immune cell function.

Main Methods:

Multicenter, randomized, double-blind, placebo-controlled trial.
150 participants with type 2 diabetes received henagliflozin (10 mg/day) or placebo for 26 weeks.
Primary endpoint: change in telomere length; secondary endpoints: metabolic and immune markers.

Main Results:

Henagliflozin significantly increased telomere length compared to placebo.
Improvements observed in glucose metabolism, insulin-like growth factor-binding protein-3, and β-hydroxybutyrate levels.
Increased granzyme B expression in cytotoxic T lymphocytes and enhanced thiamine metabolism.

Conclusions:

Henagliflozin demonstrates potential anti-aging effects by modulating telomere length and immune function.
The drug influences multiple pathways, including metabolic and cellular aging markers.
Further research is warranted to confirm these anti-aging properties in diverse populations.