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Ovatodiolide: Recent Advances in Pharmacological Activities and Mechanisms
Yingying Zhou1, Jianguo Zhang1, Qingqing Xia1
1Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Taizhou, Zhejiang Province, China.
None:
Ovatodiolide, a macrocyclic diterpenoid isolated from the traditional Chinese medicinal herb Anisomeles indica, exhibits diverse pharmacological activities in recent research. Its antitumor effects involve modulation of key signaling pathways (e.g., NF-κB/MMP-9, JAK2/STAT3, PI3K/AKT/mTOR, and Wnt/β-catenin) and effective targeting of cancer stem cells. For anti-fibrotic activity, it suppresses the TGF-β pathway and directly inhibits glucose-6-phosphate dehydrogenase. Additionally, it demonstrates antiviral, antibacterial, and anti-inflammatory activities. This review comprehensively summarizes current knowledge on ovatodiolide, including its discovery, synthesis, pharmacological actions, and underlying molecular mechanisms against target diseases. A deeper understanding of ovatodiolide's multifaceted pharmacological activities and mechanisms of action will accelerate its clinical translation as a therapeutic agent.
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