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Related Experiment Videos

Bronchial histamine challenge. A combined interrupter-dosimeter method compared with a standard method.

M Pavlovic, N H Holstein-Rathlou, F Madsen

    Allergy
    |November 1, 1985
    PubMed
    Summary

    The APTA apparatus provides a reliable method for bronchial histamine challenge, correlating well with traditional FEV1 measurements. This method is useful for routine testing when a 40-50% increase in airway resistance is the endpoint.

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    Area of Science:

    • Respiratory Medicine
    • Pulmonary Function Testing

    Background:

    • Bronchial provocation tests are crucial for diagnosing airway hyperresponsiveness.
    • Traditional methods often involve measuring FEV1 after histamine challenge.
    • Newer apparatus offer simultaneous provocation and airway resistance measurement.

    Purpose of the Study:

    • To compare provocative concentration (PC) values from a novel apparatus (APTA) with a conventional method.
    • To assess the reproducibility of histamine challenge using the APTA.

    Main Methods:

    • Histamine bronchial challenge was performed using two methods: APTA (measuring airway resistance, Rtot) and conventional tidal breathing (measuring FEV1).
    • Correlation coefficients were calculated for PC values between the two methods.
    • Reproducibility of APTA measurements was assessed.

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    Main Results:

    • High correlations were observed between PC20-FEV1 and PC30-, PC40-, and PC50-Rtot values (r=0.85, 0.71, 0.70).
    • Reproducibility for APTA was good for PC40-Rtot (r=0.65) and PC50-Rtot (r=0.70).
    • The APTA is deemed useful for routine challenge with a 40-50% increase in Rtot as the endpoint.

    Conclusions:

    • The APTA is a viable and reliable tool for bronchial histamine challenge.
    • It offers comparable results to traditional FEV1 measurements.
    • Its utility is confirmed for routine clinical use in assessing airway hyperresponsiveness.