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Overcoming standard-of-care resistance in glioblastoma using nanoparticle-based drug delivery targeting the autophagy

Md Ataur Rahman1, Mahesh Kumar Yadab1, Meser M Ali1

  • 1Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.

Biochemical Pharmacology
|September 5, 2025
PubMed
Summary

Targeting autophagy, a cellular recycling process, can overcome resistance in glioblastoma (GBM) treatment. Combining nanoparticle drug delivery systems with autophagy modulators offers a promising strategy to improve outcomes for aggressive brain tumors.

Keywords:
AutophagyBlood-brain barrier (BBB)GlioblastomaNanomedicineNanoparticle-based drug delivery (NDDS)Temozolomide (TMZ)

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Area of Science:

  • Oncology
  • Nanomedicine
  • Molecular Biology

Background:

  • Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis due to treatment resistance.
  • Autophagy contributes to GBM resistance by helping tumor cells survive stress.
  • Current therapies often fail to overcome this resistance.

Purpose of the Study:

  • To explore the potential of combining nanomedicine with autophagy modulation for GBM treatment.
  • To review nanoparticle-based drug delivery systems (NDDS) for enhancing GBM therapy.
  • To discuss strategies for overcoming drug resistance in glioblastoma.

Main Methods:

  • Review of current literature on autophagy, nanomedicine, and glioblastoma.
  • Analysis of various nanoparticle platforms (liposomes, dendrimers, etc.) for drug delivery.
  • Discussion of autophagy's role and modulation strategies in GBM.

Main Results:

  • NDDS can improve drug bioavailability, BBB penetration, and targeted delivery in GBM.
  • Nanoparticles can be designed to modulate autophagy effectively.
  • Autophagy plays a complex role in GBM, requiring context-specific modulation.

Conclusions:

  • Integrating NDDS with autophagy targeting presents a novel therapeutic approach for GBM.
  • This combination strategy holds promise for overcoming resistance and improving patient survival.
  • Targeted delivery and autophagy modulation via nanoparticles could revolutionize GBM treatment.