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Effectiveness of self-assembling peptide in reducing bleeding after colorectal endoscopic submucosal dissection
Takeshi Yamamura1, Masanao Nakamura2, Mio Hiramatsu1
1Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Gastrointestinal Endoscopy
|September 5, 2025
Summary
Self-assembling peptide (SAP) significantly reduced post-procedure bleeding and delayed bleeding (DB) after colorectal endoscopic submucosal dissection (ESD). SAP application is a key factor in preventing bleeding events following colorectal ESD.
Area of Science:
- Gastroenterology
- Biomaterials Science
- Surgical Innovation
Background:
- Self-assembling peptides (SAP) show promise for hemostasis and ulcer healing in the gastrointestinal tract.
- The efficacy of SAP in preventing post-procedural bleeding after colorectal endoscopic submucosal dissection (ESD) requires investigation.
Purpose of the Study:
- To evaluate the effectiveness of SAP in reducing hematochezia, including delayed bleeding (DB), after colorectal ESD.
- To identify SAP as a potential preventative measure for post-ESD bleeding.
Main Methods:
- A multicenter retrospective study analyzed 1,654 colorectal ESD lesions from 1,597 patients (January 2017 - July 2024).
- Lesions were categorized into non-SAP and SAP groups (719 vs. 700 lesions).
- Logistic regression analyses identified factors associated with hematochezia and DB.
Main Results:
- SAP use was significantly associated with a reduction in overall hematochezia.
- SAP significantly decreased the incidence of delayed bleeding (DB) post-ESD.
- SAP was identified as a significant protective factor against hematochezia and DB.
Conclusions:
- SAP application effectively reduces hematochezia and delayed bleeding after colorectal ESD.
- SAP is a significant factor in preventing post-endoscopic submucosal dissection bleeding.
- SAP demonstrates suitability for preventing post-ESD bleeding in the colon.
