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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Extensive Calcification of the Ventricular Septum in Gene-Positive (MYBPC3) Nonobstructive Hypertrophic

Prabhjot Hundal1, Omar Nahhas1, M Fuad Jan2

  • 1Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St Luke's Medical Centers, Milwaukee, Wisconsin, USA.

JACC. Case Reports
|September 5, 2025
PubMed

Insights

Extensive ventricular septal calcification, a rare finding after septal myectomy, was observed in a hypertrophic cardiomyopathy patient. This calcification may indicate severe myocardial fibrosis and requires comprehensive imaging evaluation.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Pathology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease.
  • Ventricular septal calcification is an uncommon finding.
  • Postsurgical changes can lead to myocardial alterations.

Purpose of the Study:

  • To present a case of extensive ventricular septal calcification.
  • To explore the association between calcification and myocardial fibrosis.
  • To highlight the diagnostic utility of multimodality imaging.

Main Methods:

  • Multimodality imaging techniques were employed.
  • Clinical data and patient history were reviewed.
  • Histopathological correlation was considered.

Main Results:

  • Extensive dystrophic calcification of the ventricular septum was identified.
  • The calcification was hypothesized to be secondary to severe myocardial fibrosis.
  • No prior reports of such findings post-septal myectomy exist.

Conclusions:

  • Ventricular septal calcification is a rare finding, particularly after septal myectomy.
  • This finding warrants thorough investigation and follow-up.
  • Multimodality imaging is crucial for comprehensive evaluation.
Abstract

Keywords:
calcificationhypertrophic cardiomyopathyseptal myectomy

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