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Updated: Sep 8, 2025
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Extensive Calcification of the Ventricular Septum in Gene-Positive (MYBPC3) Nonobstructive Hypertrophic
Prabhjot Hundal1, Omar Nahhas1, M Fuad Jan2
1Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St Luke's Medical Centers, Milwaukee, Wisconsin, USA.
JACC. Case Reports
|September 5, 2025
Summary
Extensive ventricular septal calcification, a rare finding after septal myectomy, was observed in a hypertrophic cardiomyopathy patient. This calcification may indicate severe myocardial fibrosis and requires comprehensive imaging evaluation.
Area of Science:
- Cardiology
- Medical Imaging
- Pathology
Background:
- Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease.
- Ventricular septal calcification is an uncommon finding.
- Postsurgical changes can lead to myocardial alterations.
Purpose of the Study:
- To present a case of extensive ventricular septal calcification.
- To explore the association between calcification and myocardial fibrosis.
- To highlight the diagnostic utility of multimodality imaging.
Main Methods:
- Multimodality imaging techniques were employed.
- Clinical data and patient history were reviewed.
- Histopathological correlation was considered.
Main Results:
- Extensive dystrophic calcification of the ventricular septum was identified.
- The calcification was hypothesized to be secondary to severe myocardial fibrosis.
- No prior reports of such findings post-septal myectomy exist.
Conclusions:
- Ventricular septal calcification is a rare finding, particularly after septal myectomy.
- This finding warrants thorough investigation and follow-up.
- Multimodality imaging is crucial for comprehensive evaluation.
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