MXene-Based Peroxidase-Like Nanozymes: Interfacial Effects for Biomedical Applications

MXene-based peroxidase (POD)-like nanozymes demonstrate significant potential in biomedical applications due to their 2D structure, tunable catalytic activity, and interfacial effects. This review summarizes recent advances in MXene-POD nanozyme design, focusing on interfacial effects modulation via external stimuli (e.g., near-infrared light, pH, magnetic fields) to enhance electron density distribution and catalytic efficiency. Subsequently, the emphasis transitions to their applications in biosensing, antimicrobial agents, and disease therapy, highlighting the influence of strategies on diverse applications. Finally, the recent challenges encountered by MXene-based POD-like enzymes are deliberated, along with potential avenues for future research. This review would offer crucial reference for the rational design of MXene-based POD nanozymes and their translation into biomedical applications.