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Updated: Sep 8, 2025
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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Dengue among immunocompromised patients: a systematic review and meta-analysis
Juthaporn Cowan1, Viravarn Luvira2,3, Sivaporn Gatechompol4
1Division of Infectious Diseases, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Journal of Travel Medicine
|September 6, 2025
Summary
Dengue is severe and often fatal in immunocompromised individuals, particularly after stem cell transplants (HSCT). This viral infection can persist long-term, posing risks for immunocompromised travelers.
Area of Science:
- Infectious Diseases
- Immunology
- Public Health
Background:
- Rising incidence of dengue and immunocompromised conditions globally.
- Limited data on severe dengue prevalence in immunocompromised populations.
- Need for evidence to guide immunocompromised travelers.
Purpose of the Study:
- To systematically review and meta-analyze dengue frequency and outcomes in immunocompromised individuals.
- To assess the risk of bias in existing studies.
- To inform clinical management and travel advice.
Main Methods:
- Systematic review and meta-analysis of relevant studies.
- Exclusion of non-human and review articles.
- Risk of bias assessment using the ROBINS-E tool.
Main Results:
- Eighty-five studies included; 63 had high risk of bias.
- Dengue frequency ranged from 0.3%-6.3% across cohorts.
- Severe dengue and mortality rates were significant, especially in HSCT patients (66.7% mortality).
- Dengue RNA detectable up to 2 years in urine; viable virus isolated at 9 months.
Conclusions:
- Dengue poses a high risk of severity and mortality in immunocompromised individuals, notably HSCT recipients.
- Prolonged viral persistence is a key concern.
- Findings highlight the need for cautious travel advice and management strategies.
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