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Updated: Sep 8, 2025

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
DoxyPEP: Opportunities for Expansion
En-Ling Wu1, Jade Pagkas-Bather1, Aniruddha Hazra1
1Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Abstract:
Clinical trials show that doxycycline post-exposure prophylaxis (DoxyPEP) significantly reduces the risk of bacterial sexually transmitted infections (STIs), especially syphilis and chlamydia, in cisgender men who have sex with men and transgender women. Real-world data suggest DoxyPEP may be beneficial for other populations disproportionately affected by STIs. Given the ongoing STI epidemic we recommend discussing DoxyPEP with all eligible patients. We review clinical guidelines and practical considerations surrounding DoxyPEP, highlight areas for future research, and propose strategies for implementation.
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