Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Thermoresponsive Complex Coacervates as Advanced Carriers for Cell-Laden Liquid-Core Capsules for Biomedical Applications.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Stable Protein-Based G-Quadruplex-Derived Supramolecular Bioinks as Tunable ECM-Mimetic Constructs Assembled by Combining Non-Covalent and Covalent Strategies.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Understanding Fabrication Variability in Core-Shell Soft Biomaterials Using Stochastic Artificial Intelligence.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Rapid Generation of Fusable Cell Beads for Multi-Scale Human Living Materials Assembly.

Small methods·2026
Same author

Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core-Shell Nanotransducers under Remotely Applied Magnetic Fields.

ACS nano·2025

Related Experiment Video

Updated: Sep 8, 2025

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration
14:24

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Published on: March 12, 2014

12.5K

Natural-Based Nanocomposite Ink Engineering for Seamless Multi-Material Integration in Extrusion-Based 3D Printing.

João R Maia1, Miguel Bilo1, Daniel S Fidalgo2

  • 1Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, 3810-193, Portugal.

Advanced Healthcare Materials
|September 6, 2025
PubMed
Summary

This study presents an ink engineering strategy for multi-tissue regeneration using natural nanocomposites. The developed bioinks enable seamless integration of materials, supporting cell growth and demonstrating potential for clinical applications.

Keywords:
3D printingbioactive glassfinite elementsmulti‐tissuenanocompositesnatural‐basedtissue engineering

More Related Videos

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

15.2K
3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

9.7K

Related Experiment Videos

Last Updated: Sep 8, 2025

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration
14:24

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Published on: March 12, 2014

12.5K
Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture
10:49

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

15.2K
3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

9.7K

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Multi-tissue regeneration is challenging due to complex interface requirements.
  • Existing biofabrication methods struggle with material integration and performance.

Purpose of the Study:

  • To develop an ink engineering strategy for natural nanocomposites in multi-tissue regeneration.
  • To create seamlessly integrated, robust multi-material constructs with tuneable properties.

Main Methods:

  • Utilized photocrosslinkable bovine serum albumin methacrylate (BSAMA) and hyaluronic acid methacrylate (HAMA) matrices.
  • Covalently immobilized functionalized bioactive glass nanoparticles.
  • Employed primary chemical crosslinking and secondary photocuring for 3D printing.

Main Results:

  • Engineered inks exhibited tuneable rheological properties for extrusion 3D printing.
  • BSAMA inks showed higher cytocompatibility; HAMA inks offered superior mechanical strength.
  • Combined constructs supported human adipose-derived stem cells (hASCs) proliferation and validated mechanical performance.

Conclusions:

  • The ink engineering strategy successfully integrates natural nanocomposites for multi-tissue regeneration.
  • The developed materials demonstrate bioactivity, cytocompatibility, and mechanical robustness.
  • This approach holds significant clinical potential for regenerating complex tissue interfaces.