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Natural-Based Nanocomposite Ink Engineering for Seamless Multi-Material Integration in Extrusion-Based 3D Printing
João R Maia1, Miguel Bilo1, Daniel S Fidalgo2
1Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, 3810-193, Portugal.
Advanced Healthcare Materials
|September 6, 2025
Summary
This study presents an ink engineering strategy for multi-tissue regeneration using natural nanocomposites. The developed bioinks enable seamless integration of materials, supporting cell growth and demonstrating potential for clinical applications.
Area of Science:
- Biomaterials Engineering
- Tissue Engineering
- Regenerative Medicine
Background:
- Multi-tissue regeneration is challenging due to complex interface requirements.
- Existing biofabrication methods struggle with material integration and performance.
Purpose of the Study:
- To develop an ink engineering strategy for natural nanocomposites in multi-tissue regeneration.
- To create seamlessly integrated, robust multi-material constructs with tuneable properties.
Main Methods:
- Utilized photocrosslinkable bovine serum albumin methacrylate (BSAMA) and hyaluronic acid methacrylate (HAMA) matrices.
- Covalently immobilized functionalized bioactive glass nanoparticles.
- Employed primary chemical crosslinking and secondary photocuring for 3D printing.
Main Results:
- Engineered inks exhibited tuneable rheological properties for extrusion 3D printing.
- BSAMA inks showed higher cytocompatibility; HAMA inks offered superior mechanical strength.
- Combined constructs supported human adipose-derived stem cells (hASCs) proliferation and validated mechanical performance.
Conclusions:
- The ink engineering strategy successfully integrates natural nanocomposites for multi-tissue regeneration.
- The developed materials demonstrate bioactivity, cytocompatibility, and mechanical robustness.
- This approach holds significant clinical potential for regenerating complex tissue interfaces.
