Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

146
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
146

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrogen evolution and dynamics in hydrogel electrochemical cells for ischemia-reperfusion therapy.

Nature chemical engineering·2026
Same author

Dissolving microneedle array size influences physical adjuvanticity for dose-sparing vaccination.

Biomaterials·2026
Same author

Real-world outcomes of faricimab in treatment-naïve patients with neovascular age-related macular degeneration.

BMC ophthalmology·2026
Same author

Correction: Kang et al. Endosymbiont Infections in Korean Insects: Patterns Across Orders and Habitat Types. <i>Insects</i> 2026, <i>17</i>, 71.

Insects·2026
Same author

High-flow nasal oxygen therapy reduces work of breathing without altering systemic oxygen delivery or consumption in healthy, anesthetized, spontaneously breathing dogs.

American journal of veterinary research·2026
Same author

Mineral-originated bioelectronics for inhibition via lithium electrochemistry.

Nature materials·2026
Same journal

Advanced Single-Atom Catalysts for Thermal-Catalytic C1 Chemistry.

Chemical reviews·2026
Same journal

Copper-Dependent Polysaccharide Monooxygenases: Mechanism and Function.

Chemical reviews·2026
Same journal

To Biotic or Abiotic: Biohybrid Systems for Artificial Photosynthesis.

Chemical reviews·2026
Same journal

Interfaces in All-Solid-State Li Metal Batteries: From Fundamental Research to Practical Applications.

Chemical reviews·2026
Same journal

Theoretical Terahertz Spectroscopy of Aqueous Solutions: From Electronic Structure to Molecular Understanding.

Chemical reviews·2026
Same journal

Electrochemical Electron Transfer: Key Concepts, Theories, and Parameterization via Atomistic Simulations.

Chemical reviews·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Fabrication Process of Silicone-based Dielectric Elastomer Actuators
10:32

Fabrication Process of Silicone-based Dielectric Elastomer Actuators

Published on: February 1, 2016

33.9K

Self-Regulating Hydrogel Actuators.

Taehun Chung1, Jaewon Choi1, Takafumi Enomoto2

  • 1Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH) 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, South Korea.

Chemical Reviews
|September 6, 2025
PubMed
Summary
This summary is machine-generated.

This review summarizes self-regulating hydrogels, which mimic biological systems to autonomously adapt their behavior. These intelligent soft materials offer new possibilities for advanced robotics and biomedical devices.

More Related Videos

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.3K
Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

3.1K

Related Experiment Videos

Last Updated: Apr 18, 2026

Fabrication Process of Silicone-based Dielectric Elastomer Actuators
10:32

Fabrication Process of Silicone-based Dielectric Elastomer Actuators

Published on: February 1, 2016

33.9K
An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.3K
Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

3.1K

Area of Science:

  • Materials Science
  • Soft Matter Physics
  • Biomimetic Engineering

Background:

  • Biological systems exhibit sophisticated self-regulation through feedback mechanisms.
  • Hydrogels are advanced soft materials with tunable properties.
  • Self-regulating hydrogels integrate negative feedback loops for autonomous function.

Purpose of the Study:

  • To comprehensively review design principles and implementation strategies for self-regulating hydrogel actuators.
  • To classify self-regulating hydrogels based on their regulation modes (sustained vs. one-cycle).
  • To highlight mechanisms, materials, fuels, and applications of these hydrogels.

Main Methods:

  • Systematic classification of hydrogel regulation types.
  • Analysis of underlying mechanisms, including feedback loops.
  • Review of various hydrogel compositions, chemical fuels, and performance metrics.

Main Results:

  • Self-regulating hydrogels can be categorized into sustained and one-cycle regulation.
  • Key parameters like oscillation period and amplitude are influenced by hydrogel design and fuel.
  • Diverse applications are emerging in soft robotics, sensors, and biomedical devices.

Conclusions:

  • Self-regulating hydrogel actuators show significant promise for adaptive and intelligent material systems.
  • Further research is needed to enhance robustness, modularity, and practical applications.
  • Interdisciplinary efforts can accelerate the development of advanced hydrogel-based regulatory systems.