An aggregation interpenetrating induced poly(dopamine) conductive hydrogel grid for efficient glucose detection.

Area of Science:

• Biomedical Engineering
• Materials Science
• Electrochemistry

Background:

• Continuous glucose monitoring is crucial for diabetes management.
• Existing glucose sensors face challenges in sensitivity and stability.
• Novel materials are needed to improve glucose sensing performance.

Purpose of the Study:

• To synthesize a novel glucose oxidase (GOx)/selenium (Se) hydrogel for glucose detection.
• To integrate a poly(dopamine) (PDA) conductive network for enhanced signal transduction.
• To evaluate the performance of the developed hydrogel glucose sensor.

Main Methods:

• Synthesis of GOx/Se hydrogel.
• Incorporation of poly(dopamine) (PDA) to form a conductive grid via coordination and π-π interactions.
• Electrochemical characterization of the hydrogel sensor.
• Performance evaluation including sensitivity, limit of detection, and linear range.

Main Results:

• A clustered conductive PDA grid was successfully formed within the Se hydrogel.
• The PDA hydrogel facilitated cascade catalysis and efficient electronic signal transfer.
• The sensor achieved a sensitivity of 54.4 μA mM⁻¹·cm⁻² and a limit of detection of 1.38 μM.
• PDA integration significantly enhanced sensor sensitivity compared to the control hydrogel.

Conclusions:

• The developed GOx/Se hydrogel with a PDA conductive network is a promising platform for sensitive glucose sensing.
• The unique structure enhances electron transfer, leading to improved sensor performance.
• This work offers a new strategy for designing advanced electrochemical biosensors.