Prospective Evaluation of Patient Priorities in HPV-Driven Oropharyngeal Cancer Using the Chicago Priorities Scale: Considerations for Future Clinical Trial Design
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View abstract on PubMed
Summary
This summary is machine-generated.Patient priorities for human papillomavirus-associated oropharyngeal cancer (HPVOPC) treatment remain consistent before and after chemoradiotherapy. Swallowing, senses, and mouth moisture become more important post-treatment for HPVOPC survivors.
Area Of Science
- Oncology
- Head and Neck Cancer Research
- Patient-Reported Outcomes
Background
- Human papillomavirus-associated oropharyngeal cancer (HPVOPC) is a distinct subtype of head and neck cancer.
- Treatment priorities can evolve during and after oncological therapies.
- Understanding patient priorities is crucial for tailoring treatment and supportive care.
Purpose Of The Study
- To assess the treatment outcome priorities of HPVOPC patients before and 12 months after chemoradiotherapy (CRT).
- To identify shifts in patient priorities regarding cure, survival, and quality of life post-treatment.
- To inform the development of future de-escalation treatment strategies for HPVOPC.
Main Methods
- A cohort of HPVOPC patients undergoing curative-intent primary CRT was studied.
- The Chicago Priorities Scale (CPS-modified) and MDASI Head and Neck Cancer Module (MDASI-HN) were administered.
- Descriptive statistics and statistical tests (McNemar's, general linear models) were used for analysis.
Main Results
- Key priorities like cancer cure and survival remained stable pre- and post-CRT.
- The ability to swallow was a top priority for 56% of patients post-CRT.
- Increased importance was noted for senses (taste/smell) and moist mouth post-CRT.
Conclusions
- Treatment outcome priorities for HPVOPC patients are largely stable before and 12 months after CRT.
- A significant proportion of survivors prioritize swallowing, senses, and mouth moisture post-treatment.
- Patient-centered priorities should guide the design of future de-escalation strategies in HPVOPC management.
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