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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Optimization of ciliary body cyclophotocoagulation settings: a randomized and controlled pilot study.

M Carrière1, Paul-Alexandre Pavlos Antoniades2, B Des Marchais1

  • 1Département d'Ophtalmologie et d'Ophtalmologie et d'Oto-Rhino-Laryngologie-Chirurgie Cervico-Faciale, Faculté de Médecine, Université Laval, QC, Canada; Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, Centre Hospitalier Universitaire de Québec-Université Laval, QC, Canada.

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|September 6, 2025
PubMed
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Continuous-wave transscleral cyclophotocoagulation (CW-TSCPC) effectively lowers intraocular pressure (IOP). The 1250 mW for 4 seconds setting showed comparable IOP reduction to 2000 mW for 2 seconds, with a potentially better safety profile.

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Area of Science:

  • Ophthalmology
  • Glaucoma Management
  • Surgical Techniques

Background:

  • Glaucoma management often requires interventions to control intraocular pressure (IOP).
  • Continuous-wave transscleral cyclophotocoagulation (CW-TSCPC) is an established procedure for IOP reduction.
  • Optimizing CW-TSCPC settings is crucial for balancing efficacy and safety.

Purpose of the Study:

  • To compare the efficacy and safety of two different settings for CW-TSCPC.
  • To evaluate the impact of varying energy and duration on IOP control and patient outcomes.
  • To determine the optimal CW-TSCPC parameters for glaucoma treatment.

Main Methods:

  • A prospective, randomized, triple-blind clinical trial was conducted.
  • Adult glaucoma patients received CW-TSCPC with either 1250 mW for 4 seconds (Group A) or 2000 mW for 2 seconds (Group B).
  • Outcomes measured included IOP, visual acuity, medication use, complications, and reintervention rates.

Main Results:

  • Both CW-TSCPC settings achieved comparable IOP reduction at 1, 4-6, and 12 months.
  • Group B showed a trend towards earlier medication reduction.
  • Complication rates were similar, but Group B experienced more serious complications; Group A required reintervention in 5 patients vs. 3 in Group B.

Conclusions:

  • Both CW-TSCPC settings are effective in reducing IOP.
  • The 1250 mW for 4 seconds setting may offer a superior safety profile compared to 2000 mW for 2 seconds.
  • Further research may refine CW-TSCPC protocols for enhanced glaucoma treatment outcomes.