Sodium warfarin-induced gangrene of the breast

Sodium warfarin is one of the most commonly used oral anticoagulants. It is not without complications. A case is presented of a 56-year-old woman on well-regulated sodium warfarin therapy who suffered unexplained necrosis and gangrene of the breast. She underwent total mastectomy for debridement because of the extensive nature of the infarction. Possible pathophysiological mechanisms for this process are discussed.