Related Experiment Video

Updated: Sep 8, 2025

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.0K

Transcatheter edge-to-edge repair for the management of secondary mitral regurgitation - CRT 2025 Beyond the

Dan Haberman1, Michael J Reardon2, Gregg W Stone3

  • 1Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|September 6, 2025
PubMed

Insights

Secondary mitral regurgitation (SMR) in heart failure (HF) is common and serious. New evidence suggests transcatheter edge-to-edge repair (TEER) may benefit more patients beyond current guidelines.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Heart Failure Management

Background:

  • Secondary mitral regurgitation (SMR) is a frequent complication of heart failure (HF).
  • SMR significantly worsens prognosis despite guideline-directed medical therapy (GDMT) and cardiac resynchronization therapy.
  • Current guidelines limit transcatheter edge-to-edge repair (TEER) to severe, refractory SMR.

Purpose of the Study:

  • To review current evidence and expert opinions on expanding TEER indications for SMR.
  • To identify knowledge gaps and future research directions for SMR management.
  • To inform upcoming guideline revisions for SMR treatment.

Main Methods:

  • Expert panel discussion at the 2025 Cardiovascular Research Technologies (CRT) conference.
  • Review of recent pivotal randomized controlled trials (RESHAPE-HF2, MATTERHORN, EFFORT).
  • Analysis of emerging evidence in diverse clinical scenarios.

Main Results:

  • Unresolved questions exist regarding TEER in moderate SMR, asymptomatic patients, and specific HF subsets.
  • Registry and observational data suggest procedural safety and clinical benefit of TEER in broader populations.
  • Consensus supports the need for dedicated trials in specific SMR subgroups.

Conclusions:

  • Existing guidelines may not fully encompass the evolving role of TEER in SMR.
  • Further randomized trials are needed to clarify TEER efficacy in moderate and asymptomatic SMR.
  • Broader consideration of TEER, guided by real-world data, is warranted for SMR management.

Keywords:
Heart failureM-TEERMitral regurgitation

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

1.8K
Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation06:02

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

177

Related Concept Videos

Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
27
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
20
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
80
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
39
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
53
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
47