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Related Concept Videos

Treatment Resistant Cancers02:56

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Medical Microbiology
  9. Medical Bacteriology
  11. Linezolid Versus Daptomycin For Vre Bloodstream Infections In Patients With Malignancy: The Impact Of Neutropenia On Outcomes.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Medical Microbiology
  9. Medical Bacteriology
  11. Linezolid Versus Daptomycin For Vre Bloodstream Infections In Patients With Malignancy: The Impact Of Neutropenia On Outcomes.

Related Experiment Video

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood
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Linezolid versus daptomycin for VRE bloodstream infections in patients with malignancy: The impact of neutropenia on outcomes.

Ming-Tao Tsai1, Yu-Chung Chuang1, Jia-Ling Yang1

  • 1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|September 6, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Neutropenia worsens outcomes for cancer patients with vancomycin-resistant enterococcal bloodstream infections (VRE-BSIs). Linezolid treatment in neutropenic patients showed higher mortality compared to daptomycin.

Keywords:
Bloodstream infectionHigh-dose daptomycinLinezolidMalignancy

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Area of Science:

  • Infectious Diseases
  • Hematology
  • Oncology

Background:

  • Vancomycin-resistant enterococcal bloodstream infections (VRE-BSIs) are associated with high mortality in patients with malignancy.
  • Neutropenia is a known risk factor for mortality in patients with malignancy and bloodstream infections (BSIs).
  • The impact of neutropenia on the effectiveness of daptomycin and linezolid for VRE-BSIs is not well-defined.

Purpose of the Study:

  • To evaluate the impact of neutropenia on 14-day mortality in patients with malignancy and VRE-BSI.
  • To compare the effectiveness of linezolid versus high-dose daptomycin in neutropenic and non-neutropenic patients with VRE-BSI.

Main Methods:

  • A multicenter cohort study included hospitalized patients aged ≥18 years with malignancy and VRE-BSI between 2010 and 2021.
Vancomycin-resistant enterococci
  • Patients received either linezolid or high-dose daptomycin (≥8 mg/kg).
  • Multivariable logistic regression was used to assess the primary outcome of 14-day mortality.

    • Main Results:

    • A total of 474 patients were analyzed; 128 (27.0%) had neutropenia.
    • Overall 14-day mortality was 32.9%. Mortality was higher in neutropenic patients (35.2%) than non-neutropenic patients (32.1%).
    • Among neutropenic patients, linezolid was associated with higher mortality (75.0%) compared to daptomycin (40.8%). Linezolid use in neutropenic patients was linked to increased mortality (aOR 8.48).

    Conclusions:

    • Neutropenia is associated with worse outcomes in patients with VRE-BSI.
    • Linezolid treatment in neutropenic patients with VRE-BSI was associated with higher mortality in this cohort.
    • High-dose daptomycin may be a preferred option, especially for neutropenic patients, but further research is needed.