Related Experiment Video
Updated: Jan 18, 2026

Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
The hidden connection: systemic immune-inflammation index and its role in asthma
Cheng Peng1, Dong Gao2, Zanchen Zhou3
1School of Pharmacy, Anhui University of Chinese Medicine, China.
Background:
This study explores potential associations between asthma and the Systemic Immune-Inflammation Index (SII).
Methods:
The study primarily focuses on adults with complete data on SII and asthma from the National Health and Nutrition Examination Survey database (2015-2020). SII is calculated using the formula: platelet count × neutrophil count / lymphocyte count. The connection between SII and asthma was assessed through baseline feature analysis, weighted multivariate regression, subgroup analysis, and smooth curve fitting.
Results:
A total of 13,334 participants were included, with 2045 individuals (15.34 %) having asthma. Subgroup analysis and interaction tests revealed no significant impact of gender, age, body mass index, vitamin C, magnesium, coronary heart disease, or diabetes on the observed association (p for interaction > 0.05).
Conclusion:
Higher SII levels are associated with an increased incidence of asthma. Further prospective studies are needed to confirm these findings.
Related Concept Videos
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-III: Symptoms and Complications
Classification of Asthma
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...

