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Susceptibility of Campylobacter jejuni and Campylobacter coli to macrolides and related compounds

Z Elharrif, F Mégraud, A M Marchand

    Antimicrobial Agents and Chemotherapy
    |November 1, 1985
    PubMed

    Insights

    This study assessed macrolide antibiotic susceptibility in thermophilic campylobacters from humans and swine. Human strains showed susceptibility to erythromycin and related compounds, while swine strains were largely resistant, except to pristinamycin.

    Area of Science:

    • Microbiology
    • Antimicrobial Resistance
    • Zoonotic Diseases

    Background:

    • Thermophilic campylobacters are significant human and animal pathogens.
    • Antimicrobial resistance in these bacteria poses a growing public health concern.
    • Understanding resistance patterns is crucial for effective treatment strategies.

    Purpose of the Study:

    • To determine the in vitro susceptibility of thermophilic campylobacters from human and swine sources to various macrolide antibiotics and related compounds.
    • To compare the resistance profiles between human and swine isolates.

    Main Methods:

    • Testing the susceptibility of 105 thermophilic campylobacter isolates (human and swine origins) against eight macrolides and related compounds.
    • Utilizing standard antimicrobial susceptibility testing methods.

    Main Results:

    • Human campylobacter strains exhibited susceptibility to erythromycin, josamycin, clindamycin, and ASE 136 BS.
    • Swine strains demonstrated high resistance to most tested macrolides, with notable susceptibility only to pristinamycin.
    • Human Campylobacter coli isolates generally displayed similar susceptibility patterns to Campylobacter jejuni strains.

    Conclusions:

    • Macrolide antibiotic effectiveness varies significantly between human and swine thermophilic campylobacter isolates.
    • Pristinamycin may be a potential therapeutic option for infections caused by resistant swine campylobacters.
    • The findings highlight the need for source-specific antimicrobial stewardship in managing campylobacter infections.

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