Recent advances in intelligent oxygen delivery systems for tissue regeneration

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Biomedical Engineering

Background:

• Oxygen is crucial for tissue repair and regeneration.
• Hypoxia in damaged tissues impairs healing by suppressing cell functions and delaying tissue reconstruction.
• Current oxygen delivery methods lack sustained supply, targeting, and biocompatibility.

Purpose of the Study:

• To review the biological roles of oxygen in tissue regeneration.
• To summarize recent intelligent oxygen generation and supply strategies.
• To discuss the potential and limitations of these advanced delivery systems.

Main Methods:

• Systematic review of biological functions of oxygen in tissue regeneration.
• Analysis of intelligent oxygen delivery systems responding to stimuli for dynamic release.
• Evaluation of oxygen generation mechanisms, release kinetics, and biocompatibility.

Main Results:

• Intelligent oxygen delivery systems dynamically regulate oxygen release and enable targeted delivery.
• These systems address limitations of traditional methods, enhancing oxygen therapy precision and efficacy.
• Reviewed strategies show potential for treating chronic wounds, bone defects, and myocardial infarction.

Conclusions:

• Intelligent oxygen delivery systems are promising for promoting tissue regeneration.
• Future designs should prioritize intelligent regulation for clinical translation.
• These systems offer a key approach to overcoming hypoxia-induced regeneration deficits.