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The Transmission of Clostridioides (Clostridium) difficile with a One Health Perspective
1School of Biomedical Sciences, The University of Western Australia, Queen Elizabeth II Medical Centre, Crawley 6009, Western Australia, Australia.
None:
Clostridioides difficile infection is a significant public health concern traditionally linked to health care settings. However, genomic evidence increasingly supports the spread of C difficile across humans, animals, food, and the environment with sources and reservoirs outside health care settings. Here, we review the transmission routes of C difficile within a One Health framework to uncover these complex interconnections. Understanding these pathways is essential for developing effective, integrated infection prevention and control strategies for health care and the community.
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