Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Dose Size and Dosing Frequency: Determination Methods

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

Dosage Regimen Designs: Nomograms and Tabulations

Dosage Regimen Designs: Nomograms and Tabulations

Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...

Dosage Regimens: Designs and Approaches

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Roles of Phytoestrogen in the Pathophysiology of Intracranial Aneurysm.

Stroke·2021

Same author

A case of <i>Helicobacter pylori</i> -negative early gastric adenocarcinoma with gastrointestinal phenotype.

Endoscopy international open·2021

Same author

Frequency and clinical characteristics of special types of achalasia in Japan: A large-scale, multicenter database study.

Journal of gastroenterology and hepatology·2021

Same author

Transient total blindness associated with alcoholic ketoacidosis.

Acute medicine & surgery·2021

Same author

De novo transcriptome analysis for examination of the nutrition metabolic system related to the evolutionary process through which stick insects gain the ability of flight (Phasmatodea).

BMC research notes·2021

Same author

Two hepatectomy cases for initially unresectable hepatocellular carcinoma after achieving a radiological complete response to sequential therapy with lenvatinib and transcatheter arterial chemoembolization.

Hepatology research : the official journal of the Japan Society of Hepatology·2021

Search research articles

Related Experiment Video

Updated: Jan 18, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

A novel dose-based intra-preplan method for high-dose-rate brachytherapy in cervical cancer using modeling and

Shinya Komori¹, Yoshiaki Takagawa², Hiroki Sato³

¹Department of Radiation Physics and Technology, Southern Tohoku General Hospital, Koriyama, Fukushima, Japan; Department of Radiation Physics and Technology, Southern Tohoku BNCT Research Center, Koriyama, Fukushima, Japan.

|September 7, 2025

Summary

The novel dose-based intra-preplan (DIP) method optimizes brachytherapy catheter placement for cervical cancer, using fewer catheters while maintaining treatment efficacy. This approach enhances clinical feasibility and quality of care.

Keywords:

Cervical cancer Geneva applicator High-dose-rate brachytherapy Hybrid applicator Hybrid brachytherapy

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Related Experiment Videos

Last Updated: Jan 18, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Area of Science:

Medical Physics
Radiation Oncology
Oncology

Background:

Intracavitary/interstitial brachytherapy (IC/ISBT) is crucial for cervical cancer treatment.
Optimizing catheter configuration is key to effective dose delivery and minimizing toxicity.
Current methods may not fully leverage patient-specific anatomy for optimal planning.

Purpose of the Study:

To introduce and evaluate the clinical feasibility and efficacy of the dose-based intra-preplan (DIP) method for IC/ISBT in cervical cancer.
To assess if DIP can optimize catheter configurations for improved dose distribution.
To compare DIP with conventional intra-preplan (IP) methods.

Main Methods:

The DIP method utilizes Oncentra Brachy's implant modeling and inverse planning optimization.
Virtual applicator and catheter models were merged with patient CT images.
An optimization algorithm determined optimal catheter number, positions, and depths.
Retrospective validation in 14 IC/ISBT patients using Geneva applicators.
Comparison of DIP and IP methods using dose-volume histogram (DVH) parameters for CTVHR and OARs.

Main Results:

The DIP workflow was successfully implemented.
DIP achieved comparable DVH parameters for CTVHR and OARs compared to IP.
DIP used significantly fewer catheters than the IP method (p < 0.01).
Adding catheters did not significantly improve DVH parameters, while reducing them compromised CTVHR coverage and increased OAR doses.

Conclusions:

The DIP method allows for patient-specific optimization of minimal catheter configurations in IC/ISBT.
DIP supports the wider implementation of high-quality brachytherapy for cervical cancer.
This method enhances treatment planning by focusing on optimal dose distribution.