[Racial differences in treatment and prognosis of gastric signet ring cell carcinoma: analysis based on SEER and TCGA databases]
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View abstract on PubMed
Summary
This summary is machine-generated.Racial disparities exist in gastric signet ring cell carcinoma (SRCC) tumor grade and prognosis. These findings highlight the need for tailored clinical strategies to address ethnic variations in SRCC patient outcomes.
Area Of Science
- Oncology
- Epidemiology
- Genetics
Background
- Gastric signet ring cell carcinoma (SRCC) is a distinct subtype of gastric cancer.
- Understanding racial variations in SRCC is crucial for equitable healthcare.
Purpose Of The Study
- To investigate racial differences in the prognosis of gastric signet ring cell carcinoma (SRCC).
- To analyze treatment and survival variations across different racial groups using large-scale databases.
Main Methods
- Utilized data from the US Surveillance Epidemiology and End Results (SEER) database (2000-2020).
- Categorized patients into racial cohorts: White, Black, Asian/Pacific Islander, and American Indian/Alaska Native.
- Employed demographic analysis, Kaplan-Meier survival curves, and nomogram analysis to assess prognosis and treatment.
Main Results
- A total of 2058 gastric SRCC patients were analyzed across racial groups.
- Significant racial variations were observed in tumor grade, prevalence, and survival rates (P<0.05).
- The White cohort exhibited the most pronounced differences, with notable racial disparities in patient management and overall prognosis.
Conclusions
- Racial differences significantly impact tumor grade and prognosis in gastric SRCC.
- These findings underscore the necessity for race-specific clinical diagnosis and treatment optimization for gastric SRCC.
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