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Updated: Aug 10, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
Published on: October 16, 2019
[Changes in the cerebellar cortex of rabbits subjected to an electrical current on the posterior hypothalamus]
Abstract:
After 3, 15 and 30 sessions of electrical stimulation of the hypothalamus by means of stereotaxically implanted bipolar electrodes into the area hypothalamica posterior, in the cortex of the cerebellar hemispheres, predominantly in the ganglionic layer, certain reactive, as well as poorly and intensively manifested pathological changes develop in neural and glial cells. Mosaicism of Purkinje's cells lesions within the layer, the state of their cytoplasmic matrix, granular endoplasmic reticulum and mitochondria, essential shifts in activity of oxidation-reduction enzymes at a simultaneous disorder in blood circulation and decreased content of catecholamines in the neural structures of the cerebellar vessels make it possible to estimate the process as centrogenic and neurodistrophic.

