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Mendelian randomization studies on cardiometabolic factors and intracranial aneurysms: A systematic literature

Yuge Wang1, Junyu Liu2, Fang Cao3

  • 1Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410013, China. wyg13698465622@163.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|September 8, 2025
PubMed

Insights

Elevated blood pressure is a significant risk factor for intracranial aneurysms (IA) and their subtypes. Further research is needed to clarify the roles of other cardiometabolic factors in IA development.

Area of Science:

  • Neuroscience
  • Genetics
  • Cardiology

Background:

  • Intracranial aneurysms (IA) present insidious onset, leading to high mortality and disability upon rupture.
  • Cardiometabolic factors are potential contributors to IA formation and rupture.

Purpose of the Study:

  • To systematically review Mendelian randomization (MR) studies investigating the association between cardiometabolic factors and IA.
  • To provide insights into the etiology and pathogenesis of IA.

Main Methods:

  • Comprehensive literature search of MR-based IA studies up to February 21, 2024, across major databases.
  • Independent screening, data extraction, and quality assessment by two researchers.
  • Qualitative systematic review using a narrative synthesis approach.

Main Results:

  • Eleven MR studies (2017-2024) were included; 4 were high-quality.
  • Consistent evidence identified blood pressure as a risk factor for IA and its subtypes.
  • Inconsistent findings were reported for blood lipids, blood glucose, obesity, and inflammatory cytokines.

Conclusions:

  • Blood pressure is implicated as a risk factor for intracranial aneurysms.
  • Causal relationships between other cardiometabolic factors and IA require further investigation.
  • Causal inferences from MR studies should be made cautiously, integrating with other evidence.
Abstract

Keywords:
Mendelian randomizationcardiometabolic factorscausalitygenetic epidemiologyintracranial aneurysm

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