Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.3K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.3K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of visit schedule on estimated success rates in glaucoma surgical studies.

The British journal of ophthalmology·2026
Same author

Optical coherence tomography to identify upper airway obstruction sites in an apneic patient.

Biophotonics discovery·2026
Same author

Erratum: Publisher's Note: Optical coherence tomography to identify upper airway obstruction sites in an apneic patient.

Biophotonics discovery·2026
Same author

A vision transformer model for the detection of glaucoma from optic disc photographs.

Scientific reports·2026
Same author

Detection of Structural Glaucoma Progression with Deep Learning on Serial Optic Disc Photographs.

Ophthalmology. Glaucoma·2026
Same author

The Incidence of Clinically Significant Hypotony After Trabeculectomy.

Journal of glaucoma·2026
Same journal

Assessing Polypoidal Choroidal Vasculopathy-Related OCT Features in the TENAYA and LUCERNE Trials.

Ophthalmology science·2026
Same journal

Quantitative Analysis of Choroidal Thickness and Blood Flow in Thyroid-Associated Ophthalmopathy Using Ultra-Widefield Swept-Source OCT Angiography.

Ophthalmology science·2026
Same journal

Epiretinal Membrane Is Associated with Acquired Vitelliform Lesion Morphometrics in Intermediate Age-Related Macular Degeneration.

Ophthalmology science·2026
Same journal

Multisource Machine Learning Model for Detecting Referral-Warranted Retinopathy of Prematurity.

Ophthalmology science·2026
Same journal

Association of Tirzepatide versus Glucagon-Like Peptide-1 Receptor Agonists with Incident Glaucoma in Patients with Type 2 Diabetes: A Retrospective Cohort Study.

Ophthalmology science·2026
Same journal

Regional Biomechanical and Topographic Changes after Transepithelial vs. Epithelium-off Continuous Accelerated Corneal Cross-linking in Keratoconus: Updated Stress-Strain Index as a Superior Biomarker.

Ophthalmology science·2026
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
06:16

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies

Published on: July 28, 2023

3.0K

A Joint Bayesian Longitudinal Model for Macular Structure-Function Correlations in Glaucoma.

Erica Su1, Kwanghyun Lee1,2, Abraham Liu3

  • 1Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

Ophthalmology Science
|September 8, 2025
PubMed
Summary
This summary is machine-generated.

This study used a Bayesian model to analyze glaucoma progression, finding positive correlations between retinal nerve fiber layer thickness and visual field sensitivity. The model offers improved accuracy for monitoring disease advancement.

Keywords:
Bayesian bivariate longitudinal modelGanglion cell complexMacular OCTMean deviationVisual field

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K
A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

11.0K

Related Experiment Videos

Last Updated: Jan 18, 2026

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
06:16

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies

Published on: July 28, 2023

3.0K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K
A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

11.0K

Area of Science:

  • Ophthalmology
  • Biostatistics
  • Medical Imaging

Background:

  • Glaucoma is a progressive optic neuropathy characterized by vision loss.
  • Accurate monitoring of glaucoma progression is crucial for effective patient management.
  • Longitudinal structure-function relationships are key to understanding disease dynamics.

Purpose of the Study:

  • To investigate longitudinal structure-function (SF) relationships in glaucoma.
  • To assess the relationship between macular ganglion cell complex (GCC) thickness and visual field (VF) mean deviation (MD) rates of change.
  • To utilize a Bayesian joint bivariate longitudinal model for this investigation.

Main Methods:

  • Prospective cohort study of 117 glaucoma patients over 2+ years.
  • Optical coherence tomography (OCT) for GCC thickness and automated perimetry for VF MD.
  • Bayesian joint bivariate longitudinal model to estimate correlations and compare with simple linear regression (SLR) via simulation.

Main Results:

  • Mean correlation between baseline GCC and MD was 0.47.
  • Mean correlation between rates of change (slopes) was 0.29.
  • The Bayesian model showed improved accuracy over SLR in estimating slope correlations.

Conclusions:

  • The Bayesian joint model enhances accuracy and reduces uncertainty in estimating glaucoma SF relationships.
  • Significantly positive correlations exist between global SF rates of change.
  • This model is a step towards developing local longitudinal SF models for improved glaucoma monitoring.