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Updated: May 9, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
Published on: December 3, 2015
Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applications
Jiaqi Huang1, Aishik Chakraborty1,2, Yasmeen Shamiya3
1Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9 Canada.
Abstract:
We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating bone defects and methicillin-resistant Staphylococcus aureus (MRSA) infection using in vitro studies. We successfully synthesized TDNs and demonstrated their excellent cytocompatibility with blood cells and immune cells. Zoledronic acid-loaded TDN displayed increased efficacy compared to free drugs in regulating bone remodeling, while vancomycin-loaded TDN showed an increased antibacterial effect against MRSA. In the future, this nano-drug delivery platform, with its multifunctional properties, can be potentially used to treat bone fractures and surgery-related MRSA infection.
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