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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Related Experiment Video

Updated: Jan 18, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

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Wound healing and signaling pathways.

Zhe Liu1, Yudong Fang1

  • 1Shanghai TCM-Integrated Hospital, Department of Vascular Diseases, Shanghai University of TCM, No. 230, Baoding Road, Hongkou District, Shanghai, Shanghai Municipality, 200082, China.

Open Life Sciences
|September 8, 2025
PubMed
Summary

This review details signaling pathways crucial for wound healing, covering inflammation, regeneration, and remodeling. It explores therapeutic strategies for improved healing outcomes.

Keywords:
crosstalksignaling pathwaytherapeutic strategieswound healing

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Wound healing is a complex biological process regulated by intricate signaling pathways.
  • Dysregulation of these pathways can lead to chronic or impaired wound healing.
  • Understanding these molecular mechanisms is vital for developing effective treatments.

Purpose of the Study:

  • To comprehensively review signaling pathways involved in wound healing.
  • To discuss the role of pathway crosstalk in wound healing dysregulation.
  • To explore emerging therapeutic strategies targeting these pathways.

Main Methods:

  • Literature review of signaling pathways in wound healing.
  • Analysis of pathway interactions and their impact on healing.
  • Summary of preclinical and clinical data for therapeutic interventions.

Main Results:

  • Signaling pathways orchestrate inflammation, vascular regeneration, cell proliferation, and extracellular matrix remodeling.
  • Pathway crosstalk significantly influences the success or failure of wound healing.
  • Various therapeutic strategies, including small molecules, gene therapy, and biologics, show promise.

Conclusions:

  • Elucidating molecular mechanisms of wound healing is key to advancing therapeutic applications.
  • Targeting specific signaling pathways offers potential for novel wound healing interventions.
  • Further research and translational studies are needed to optimize therapeutic efficacy.