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Exploring the Correlation Between the Serum Homocysteine to Apolipoprotein A1 Ratio and the Severity of Coronary

Jingshui Zhang1, Zufei Wu1,2, Niannian Liu1

  • 1Department of Cardiology, Xuancheng People's Hospital, Xuancheng, Anhui, People's Republic of China.

Journal of Inflammation Research
|September 8, 2025
PubMed

Insights

The serum homocysteine (HCY) to apolipoprotein A-1 (ApoA-1) ratio (HAR) is linked to coronary artery disease (CAD). This ratio shows predictive value for CAD and severe CAD, aiding in diagnosis.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Diagnostics

Background:

  • Coronary Artery Disease (CAD) is a significant global health concern.
  • Biomarkers for assessing CAD risk and severity are crucial for effective patient management.
  • The homocysteine (HCY) to apolipoprotein A-1 (ApoA-1) ratio (HAR) is an emerging marker.

Purpose of the Study:

  • To investigate the correlation between the serum HAR and the presence and severity of CAD.
  • To evaluate the predictive value of HAR in patients with suspected coronary artery disease.

Main Methods:

  • Patients undergoing coronary angiography were recruited from two medical centers.
  • Serum levels of HCY, ApoA-1, albumin, and other indicators were measured.
  • Statistical analyses, including multivariable logistic regression and correlation analysis, were performed to assess the relationship between HAR and CAD.

Main Results:

  • A linear relationship was observed between HAR and CAD incidence.
  • HAR was identified as an independent risk factor for both CAD and severe CAD.
  • The predictive model incorporating HAR demonstrated good predictive value for severe coronary artery lesions (C-indexes 0.719 for CAD, 0.837 for severe CAD).
  • A significant positive correlation was found between HAR and the Gensini score, indicating a link to lesion severity.

Conclusions:

  • The serum HAR is discernibly correlated with coronary artery disease (CAD).
  • HAR possesses predictive value for both the presence and severity of CAD.
  • HAR serves as a valuable tool for the diagnosis and assessment of coronary heart disease.
Abstract

Keywords:
apolipoprotein A1coronary artery diseasehomocysteineratio of homocysteine to apolipoprotein A1

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