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Updated: Jul 2, 2026

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT
Published on: May 27, 2012
Diffusivity-limited q-space trajectory imaging
Deneb Boito1,2, Magnus Herberthson3, Tom Dela Haije4
1Department of Biomedical Engineering, Campus US, Linköping University, Linköping, SE-581 83, Sweden.
None:
Q-space trajectory imaging (QTI) allows non-invasive estimation of microstructural features of heterogeneous porous media via diffusion magnetic resonance imaging performed with generalised gradient waveforms. A recently proposed constrained estimation framework, called QTI+, improved QTI's resilience to noise and data sparsity, thus increasing the reliability of the method by enforcing relevant positivity constraints. In this work we consider expanding the set of constraints to be applied during the fitting of the QTI model. We show that the additional conditions, which introduce an upper bound on the diffusivity values, further improve the retrieved parameters on a publicly available human brain dataset as well as on data acquired from healthy volunteers using a scanner-ready protocol.
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