The relationship between hematological parameters and coronary angiographic lesions
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Updated: Jan 18, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Thadzia Maria de Brito Ramos1, José Gildo de Moura Monteiro Júnior1, Veridiana Câmara Furtado1
1Pernambuco Cardiac Emergency Hospital, University of Pernambuco (PROCAPE, UPE), Recife, Brazil.
Insights
Hematological parameters like nucleated red blood cells (NRBCs), neutrophil to lymphocyte ratio (NLR), and mean platelet volume (MPV) can help assess acute myocardial infarction severity. These biomarkers correlate with coronary artery disease complexity, offering potential prognostic tools.
Area of Science:
- Cardiology
- Hematology
- Inflammation Research
Background:
- Atherosclerosis, a key cause of acute myocardial infarction (AMI), involves complex inflammatory processes.
- Hematological variables are increasingly recognized as potential biomarkers for coronary artery disease (CAD) severity.
Purpose of the Study:
- To review the relationship between specific hematological parameters and coronary angiographic findings in AMI patients.
- To explore the utility of hematological parameters as in-hospital prognostic tools for AMI.
Main Methods:
- Review of current literature linking hematological parameters (NRBCs, NLR, MPV) with CAD.
- Discussion of inflammatory mechanisms in plaque formation and their link to hematological changes.
- Exploration of existing scoring systems (e.g., SYNTAX score) for CAD complexity.
Main Results:
- Hematological parameters such as nucleated red blood cells (NRBCs), neutrophil to lymphocyte ratio (NLR), and mean platelet volume (MPV) show correlations with CAD severity.
- Inflammation in coronary atherosclerotic disease stimulates bone marrow to release immature cells, contributing to thrombotic plaque formation.
- These hematological markers may serve as components of a laboratory model for in-hospital surveillance.
Conclusions:
- Hematological biomarkers demonstrate a significant relationship with coronary atherosclerotic plaques.
- These parameters hold potential as in-hospital prognostic tools for AMI patients.
- The interplay between hematological markers and atherosclerotic plaques may represent a future therapeutic target.
Abstract:
Atherosclerosis is the most important etiology of acute myocardial infarction, which is considered an inflammatory disease with specific cellular and molecular responses. Recent research has linked hematological variables as biomarkers of the severity of coronary artery disease. Studies suggest that nucleated red blood cells (NRBCs), neutrophil to lymphocyte ratio (NLR), and mean platelet volume (MPV) may serve as components of a laboratory model or hematological scoring system for in-hospital surveillance. Atherosclerotic plaques can be graded using scoring systems, such as the SYNTAX score which is used to evaluate the complexity of coronary artery disease. However, there is an open field for research to explain the complex inflammatory mechanism of these plaques. Research has shown that inflammatory processes, such as those seen in coronary atherosclerotic disease, stimulate the bone marrow to release young and immature cells into the systemic circulation, which actively aggregate and, consequently, form thrombotic plaques. This mini review article aims to demonstrate the relationship between hematological parameters and coronary angiographic findings as potential in-hospital prognostic tools for patients with acute myocardial infarction. This expressive relationship between these hematological biomarkers and coronary atherosclerotic plaques may be a target, in addition to prognostic scores, of future therapeutic interventions.
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