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Causal associations between inflammatory cytokines and hypertensive disorders
Xiaosong Li1, Zhaoting Gong1, Yuejin Yang2
1Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Clinical Hypertension
|September 8, 2025
Summary
This study reveals fibroblast growth factor 5 (FGF5) is causally linked to hypertensive disorders. Targeting inflammatory pathways, like MAPK, may offer new hypertension treatments.
Area of Science:
- Cardiovascular Research
- Genetics
- Immunology
Background:
- Hypertensive disorders are linked to inflammatory cytokines (ICs).
- Causal relationships between ICs and hypertension require further investigation.
Purpose of the Study:
- To establish causal links between 91 ICs and hypertensive disorders using Mendelian randomization (MR).
- To identify specific ICs and pathways involved in hypertension development.
Main Methods:
- Utilized genome-wide association study data for 91 ICs and hypertensive traits.
- Performed MR analyses with inverse variance weighting, MR-Egger, and weighted median methods.
- Conducted Gene Ontology, KEGG, and protein-protein interaction (PPI) network analyses for significant ICs.
Main Results:
- Identified 18 ICs significantly associated with hypertensive disorders.
- Fibroblast growth factor 5 (FGF5) showed unique associations with hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP).
- FGF5 emerged as a central hub in PPI networks, implicating the MAPK signaling pathway.
Conclusions:
- Fibroblast growth factor 5 (FGF5) plays a key role in hypertensive disorder pathogenesis.
- The mitogen-activated protein kinase (MAPK) signaling pathway is implicated in hypertension.
- Targeting inflammatory pathways presents potential therapeutic strategies for hypertension.
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