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Causal associations between inflammatory cytokines and hypertensive disorders

Xiaosong Li1, Zhaoting Gong1, Yuejin Yang2

  • 1Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Clinical Hypertension
|September 8, 2025
PubMed

Insights

This study reveals fibroblast growth factor 5 (FGF5) is causally linked to hypertensive disorders. Targeting inflammatory pathways, like MAPK, may offer new hypertension treatments.

Area of Science:

  • Cardiovascular Research
  • Genetics
  • Immunology

Background:

  • Hypertensive disorders are linked to inflammatory cytokines (ICs).
  • Causal relationships between ICs and hypertension require further investigation.

Purpose of the Study:

  • To establish causal links between 91 ICs and hypertensive disorders using Mendelian randomization (MR).
  • To identify specific ICs and pathways involved in hypertension development.

Main Methods:

  • Utilized genome-wide association study data for 91 ICs and hypertensive traits.
  • Performed MR analyses with inverse variance weighting, MR-Egger, and weighted median methods.
  • Conducted Gene Ontology, KEGG, and protein-protein interaction (PPI) network analyses for significant ICs.

Main Results:

  • Identified 18 ICs significantly associated with hypertensive disorders.
  • Fibroblast growth factor 5 (FGF5) showed unique associations with hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP).
  • FGF5 emerged as a central hub in PPI networks, implicating the MAPK signaling pathway.

Conclusions:

  • Fibroblast growth factor 5 (FGF5) plays a key role in hypertensive disorder pathogenesis.
  • The mitogen-activated protein kinase (MAPK) signaling pathway is implicated in hypertension.
  • Targeting inflammatory pathways presents potential therapeutic strategies for hypertension.
Abstract

Keywords:
FGF5HypertensionInflammatory cytokinesMAPK signaling pathwayMendelian randomization

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