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Related Concept Videos

Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Related Experiment Video

Updated: Jan 18, 2026

Wideband Optical Detector of Ultrasound for Medical Imaging Applications
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Ultrasound Imaging and Machine Learning for Nondestructive Sensing in Bioreactors.

Mary Serpe1, Caleb Lee1, Reid Povinelli1

  • 1Department of Engineering, Boston College, 245 Beacon Street, Chestnut Hill, Massachusetts 02446, United States.

ACS Omega
|September 8, 2025
PubMed
Summary
This summary is machine-generated.

Ultrasound imaging offers a noninvasive method to monitor cell growth in cellular agriculture. This technology can assess plant scaffolds, ensuring quality control in large-scale cell production without damaging samples.

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Area of Science:

  • Biotechnology
  • Cellular Agriculture
  • Biomedical Engineering

Background:

  • Cell therapy and cellular agriculture require scalable, noninvasive monitoring methods.
  • Bioreactors need robust quality control for efficient cell production.
  • Current monitoring techniques can be invasive or costly.

Purpose of the Study:

  • To investigate ultrasound technology for characterizing cellular growth and decellularization in plant-based scaffolds.
  • To assess the feasibility of using ultrasound as a nondestructive quality control tool in cellular agriculture.

Main Methods:

  • Ultrasound imaging was performed on fresh spinach leaves, decellularized leaves, and seeded scaffolds.
  • Machine learning algorithms were used for image segmentation and analysis.
  • Statistical analysis compared pixel intensity differences between sample types.
  • Histological analysis served as a validation method.

Main Results:

  • Significant differences in mean pixel intensity were observed between fresh and decellularized spinach leaves (p < 0.001).
  • Distinct intensity variations were detected between decellularized regions with and without seeded cells (p = 0.001).
  • Histological analysis corroborated the ultrasound findings.

Conclusions:

  • Ultrasound imaging shows promise as a viable, nondestructive tool for assessing plant scaffolds in cellular agriculture.
  • This method can aid in quality assessment during large-scale cell production.
  • Ultrasound offers a cost-effective and efficient alternative for monitoring cell growth and scaffold integrity.