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One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

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This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
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The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
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Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
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Related Experiment Video

Updated: Jan 18, 2026

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
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Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

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Segmentation of partial least squares structural equation modelling using kernel K-means clustering (PLS SEM KKC).

Cindy Cahyaning Astuti1,2, Bambang Widjanarko Otok1, Shofi Andari1

  • 1Department of Statistics, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia.

Methodsx
|September 8, 2025
PubMed
Summary

This study introduces PLS SEM Kernel K-Means Clustering (PLS SEM KKC) for improved segmentation. This novel method effectively addresses unobserved heterogeneity by capturing non-linear patterns, significantly enhancing Partial Least Squares Structural Equation Modeling accuracy.

Keywords:
Kernel K-Means ClusteringPLS SEMSegmentation

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From Voxels to Knowledge: A Practical Guide to the Segmentation of Complex Electron Microscopy 3D-Data
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Area of Science:

  • Statistical Modeling
  • Machine Learning Applications
  • Multivariate Data Analysis

Background:

  • Partial Least Squares Structural Equation Modeling (PLS SEM) is widely used but limited by unobserved heterogeneity.
  • Existing PLS SEM segmentation methods rely on linear clustering, failing to capture non-linear residual patterns.
  • Unobserved heterogeneity can lead to inaccurate and unreliable PLS SEM models.

Purpose of the Study:

  • To propose and evaluate a novel non-linear segmentation method for PLS SEM, named PLS SEM Kernel K-Means Clustering (PLS SEM KKC).
  • To address the limitation of unobserved heterogeneity in PLS SEM by incorporating kernel-based clustering.
  • To enhance the accuracy and reliability of PLS SEM models through effective segmentation.

Main Methods:

  • Developed PLS SEM Kernel K-Means Clustering (PLS SEM KKC) by integrating kernel-based clustering with PLS SEM.
  • Segmentation was performed based on the non-linear residual values from measurement and structural models of a global PLS SEM.
  • Employed clustering to group observations with similar residual patterns into homogeneous segments.

Main Results:

  • The PLS SEM KKC method significantly improved model accuracy compared to the global model.
  • R² values increased from 51.1% (global model) to 93.9% (k=2) and 97.5% (k=3) in segmented clusters.
  • The substantial increase in local R² demonstrates the successful overcoming of unobserved heterogeneity.

Conclusions:

  • PLS SEM KKC is a recommended new method for PLS SEM segmentation.
  • The method effectively captures non-linear residual patterns, successfully addressing unobserved heterogeneity.
  • PLS SEM KKC leads to more accurate and robust PLS SEM models by creating homogeneous segments.