Supranuclear Vertical Gaze Palsy in Movement Disorders.
Mehri Salari1, Alireza Alikhani1, Fatemeh Hojjati Pour2
1Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shohada Tajrish Hospital, Tehran, Iran.
Neuro-Ophthalmology (Aeolus Press)
|September 8, 2025
Summary
Vertical gaze palsy, an eye movement disorder, is linked to numerous neurological conditions. Recognizing its diverse manifestations is key for accurate diagnosis and effective patient management.
Area of Science:
- Neurology
- Ophthalmology
- Movement Disorders
Background:
- Vertical gaze palsy involves impaired eye movement.
- It is associated with a wide range of neurological disorders.
- Accurate diagnosis and management are crucial.
Purpose of the Study:
- To provide an overview of vertical gaze palsy.
- To discuss its manifestation in various movement disorders.
- To highlight clinical relevance for practitioners.
Main Methods:
- Non-systematic literature search on PubMed.
- Keywords included 'gaze palsy', 'vertical gaze palsy', 'gaze abnormality', 'eye movement disorder'.
Main Results:
- Vertical gaze palsy occurs in Parkinson's disease, atypical Parkinsonian syndromes, Niemann-Pick disease type C, Wilson's disease, Whipple's disease, and prion disease.
- It is associated with neurodegenerative, metabolic, infectious, and autoimmune disorders, as well as substance/medication intoxication.
- Differential diagnosis is complex due to overlapping presentations.
Conclusions:
- Vertical gaze palsy is a symptom with diverse etiologies.
- Understanding its varied presentations aids in diagnosis.
- This review assists practitioners in managing patients with this condition.
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