Real-World Experience of Geographic Atrophy Treatment With Avacincaptad Pegol
Abdullah Abou-Samra1,2, Muhi Dean Barazi1,3, Amira Abbas2
1Retina Group of Washington, Reston, VA, USA.
Journal of Vitreoretinal Diseases
|September 8, 2025
Summary
Real-world data show avacincincaptad pegol (a treatment for geographic atrophy) has a generally favorable safety profile. Adverse events were infrequent, with low rates of elevated intraocular pressure and conversion to neovascular AMD.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacovigilance
Background:
- Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD).
- Avacincaptad pegol is a novel therapeutic agent for GA.
- Real-world safety data are crucial for understanding treatment risks.
Purpose of the Study:
- To evaluate the real-world safety and clinical experience of avacincaptad pegol in a large cohort of GA patients.
- To identify adverse events associated with avacincaptad pegol treatment.
Main Methods:
- Retrospective, observational cohort study.
- Data collected from PRISM Vision Group using J codes for avacincaptad pegol (August 2023 - October 2024).
- Included 461 eyes from 335 patients treated with intravitreal avacincaptad pegol 2 mg.
Main Results:
- Mean follow-up: 120 days; mean injection interval: 52 days.
- 14 eyes (3%) experienced acute intraocular pressure rise; no endophthalmitis or optic neuropathy reported.
- 8 eyes (2.03%) converted to neovascular AMD; 1 eye (0.2%) had vitreous hemorrhage.
Conclusions:
- Avacincaptad pegol demonstrates a manageable safety profile in real-world GA treatment.
- Findings support clinicians in assessing risks of adverse events with this GA therapy.
- Further monitoring is essential for this emerging treatment.
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