Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Performance of Prespecified OCT Rules for Glaucomatous Optic Neuropathy in Nonpathologic Myopia.

JAMA ophthalmology·2026
Same author

Evidence and Consensus Based Guidelines for Imaging in Tubercular Choroiditis. Multimodal imaging in Uveitis (MUV) Taskforce: Report 17.

Ophthalmology. Retina·2026
Same author

Interpretable Framework for Sleep Monitoring: Applying Statistical Control Charts to Physiological Data Streams.

Sensors (Basel, Switzerland)·2026
Same author

Choroidal imaging features of KIF11-associated retinopathy: expanding the ocular phenotype.

International journal of retina and vitreous·2026
Same author

EyeRAG: graph retrieval-augmented generation for safe and accurate clinical dialogue in ophthalmology.

NPJ digital medicine·2026
Same author

Drug therapies and immune pathways in ocular manifestations of inflammatory skin diseases.

Expert review of clinical immunology·2026
Same journal

Structure-Function Correlation With Optical Coherence Tomography-Derived Macular Thickness and Macular Microperimetry in Children, Adolescents, and Young Adults With Sickle Cell Disease.

Journal of vitreoretinal diseases·2026
Same journal

Modified Scleral Fixation for Intraocular Lenses With Unloopable Haptic Designs.

Journal of vitreoretinal diseases·2026
Same journal

Factors Influencing Visual and Refractive Outcomes for Scleral-Sutured Intraocular Lenses.

Journal of vitreoretinal diseases·2026
Same journal

Clinical Features and Surgical Outcomes of Various Scleral Buckle Techniques in Rhegmatogenous Retinal Detachment.

Journal of vitreoretinal diseases·2026
Same journal

Optical Coherence Tomography Biomarkers as Potential Predictors for Visual Function and Response to Intravitreal Therapy in Diabetic Macular Edema.

Journal of vitreoretinal diseases·2026
Same journal

Surgical Management of Maculopathy in Papillorenal Syndrome: Insights From 2 Cases With PAX2 Mutations.

Journal of vitreoretinal diseases·2026
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
07:35

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility

Published on: April 21, 2022

2.6K

Retinal Layer Thickness and Volume Measurements in Traumatic Brain Injury.

Naveen Karthik1, Sejal D Patel1, Grant A Justin2

  • 1iMIND Study Group, Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.

Journal of Vitreoretinal Diseases
|September 8, 2025
PubMed
Summary
This summary is machine-generated.

Traumatic brain injury (TBI) can alter retinal layer thickness and volume, particularly the ganglion cell-inner plexiform layer and outer plexiform layer. These changes may worsen over time following TBI.

Keywords:
neurodegenerative diseasesretinatraumatic brain injury

More Related Videos

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.9K
Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope
08:25

Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope

Published on: April 21, 2023

1.6K

Related Experiment Videos

Last Updated: Jan 18, 2026

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
07:35

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility

Published on: April 21, 2022

2.6K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.9K
Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope
08:25

Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope

Published on: April 21, 2023

1.6K

Area of Science:

  • Ophthalmology
  • Neurology
  • Medical Imaging

Background:

  • Traumatic brain injury (TBI) is a significant public health concern.
  • Ocular changes following TBI are increasingly recognized.
  • Optical coherence tomography (OCT) allows for detailed retinal layer analysis.

Purpose of the Study:

  • To evaluate retinal layer thickness and volume using OCT in individuals with a history of TBI.
  • To investigate potential correlations between TBI characteristics and retinal structural changes.

Main Methods:

  • Prospective recruitment of adult patients with prior TBI and age/sex-matched controls.
  • Macular cube scans acquired using Zeiss Cirrus HD-5000 OCT.
  • Semiautomated segmentation (manual correction) of key retinal layers (GC-IPL, INL, OPL, ONL, PR, RPE) and analysis of thickness/volume in ETDRS rings.

Main Results:

  • Male TBI patients showed decreased mean ganglion cell-inner plexiform layer (GC-IPL) thickness and increased mean outer plexiform layer (OPL) thickness/volume compared to controls.
  • Moderate TBI eyes exhibited increased neurosensory retina, INL, OPL, and RPE thickness/volume.
  • Nonpenetrating contact TBI eyes had increased neurosensory retina and ONL thickness/volume compared to acceleration-deceleration TBI.
  • Decreasing GC-IPL thickness/volume correlated significantly with time elapsed since TBI.

Conclusions:

  • TBI can lead to measurable alterations in retinal layer thickness and volume.
  • Retinal changes associated with TBI may be progressive over time.
  • OCT is a valuable tool for detecting TBI-related ocular pathology.