Hyperuricemia in Chinese Patients with Mood Disorders: Prevalence, Related Factors, and Predictive Model
Xinyue Wang1, Sili Wang2, Wenbo Qi3
1Acute Intervention Department (Female III Part), Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen, Guangdong, People's Republic of China.
Neuropsychiatric Disease and Treatment
|September 8, 2025
Summary
Hyperuricemia is common in mood disorders, particularly bipolar disorder. Lithium carbonate treatment and metabolic factors like triglycerides are linked to higher uric acid levels in these patients.
Area of Science:
- Psychiatry
- Metabolic Disorders
- Pharmacology
Background:
- Serum uric acid (UA) levels are elevated in bipolar disorder (BD) compared to other conditions.
- A complex bidirectional relationship exists between mood disorders (MD) and hyperuricemia (HUA).
Purpose of the Study:
- Investigate the prevalence and contributing factors of hyperuricemia in Chinese mood disorder patients.
- Identify potential mechanisms and develop a predictive model for hyperuricemia in MD.
Main Methods:
- Enrolled 771 mood disorder patients.
- Collected demographic and clinical data, including depression severity (HAMD-17), psychotic symptoms (PANSS), and suicide risk (NGASR).
- Analyzed metabolic parameters, liver function, and blood cell counts.
Main Results:
- Hyperuricemia prevalence: 21.68% in depressive disorder, 39.25% in bipolar disorder depressive episodes.
- Independent risk factors for hyperuricemia included lithium carbonate, urea, triglycerides, LDH, and WBC.
- Developed a predictive model using these factors plus platelets, albumin, ALT, and C-peptide.
Conclusions:
- Close monitoring of uric acid levels is crucial for MD patients on lithium carbonate.
- Hepatic triglyceride accumulation and drug-induced liver damage may contribute to hyperuricemia in mood disorders.
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