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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
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Inflammatory-Driven Vitamin A Transport Dysfunction in Ulcerative Colitis.

Zhe Zhou1,2,3, Junming Miao1,4, Yang Jing1,4

  • 1Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|September 8, 2025
PubMed
Summary
This summary is machine-generated.

Serum retinol-binding protein 4 (RBP4) levels are lower in ulcerative colitis (UC) patients and decrease with disease severity. This suggests RBP4 suppression by inflammation may impair vitamin A transport in UC.

Keywords:
inflammationliver-gut axisretinol binding protein 4ulcerative colitisvitamin A

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Area of Science:

  • Immunology
  • Nutritional Science
  • Gastroenterology

Background:

  • Retinol-binding protein 4 (RBP4) is a key vitamin A transporter involved in inflammation and immune regulation.
  • Low serum vitamin A is observed in ulcerative colitis (UC) patients, but the role of RBP4 and vitamin A transport mechanisms in UC remain unclear.

Purpose of the Study:

  • To investigate the association between serum RBP4 levels and vitamin A levels in UC patients.
  • To explore the underlying mechanisms of impaired vitamin A transport during UC inflammation.

Main Methods:

  • Serum RBP4 and vitamin A levels were measured in 103 UC patients and 22 controls using ELISA.
  • Correlations with disease severity and treatment response were assessed.
  • A DSS-induced colitis mouse model and primary hepatocyte cultures were used to evaluate RBP4 expression under inflammatory conditions.

Main Results:

  • UC patients exhibited significantly lower serum RBP4 and vitamin A levels compared to controls.
  • Both vitamin A and RBP4 levels decreased with increasing UC disease severity and improved after treatment.
  • Hepatic RBP4 expression was reduced in a mouse model of colitis and negatively correlated with pro-inflammatory cytokines (TNF-α, IL-6, IL-17).

Conclusions:

  • Serum RBP4 levels are decreased in UC patients and correlate negatively with disease severity.
  • Pro-inflammatory cytokines may suppress RBP4 expression, potentially contributing to vitamin A transport dysfunction in UC.