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Related Concept Videos

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Related Experiment Video

Updated: Jan 18, 2026

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Incorporating microbiomes into the One Health Joint Plan of Action.

Estelle Couradeau1, Jennifer B H Martiny2, Fanette Fontaine3

  • 1Department of Ecosystem Science and Management, The Pennsylvania State University, University Park, Pennsylvania, USA.

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|September 8, 2025
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Summary

The One Health initiative needs to include microbiomes to effectively address global health challenges. Integrating microbiome science offers sustainable solutions for zoonotic diseases, antimicrobial resistance, and environmental health.

Keywords:
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Area of Science:

  • Microbiome science
  • Global health
  • Ecosystem health

Background:

  • The One Health Joint Plan of Action (2022-2026) addresses global health risks at the human-animal-plant-environment interface.
  • Current frameworks overlook the crucial role of microbiomes in ecosystem health and disease regulation.
  • Microbiomes are essential for nutrient cycling, pathogen suppression, antimicrobial resistance (AMR) dynamics, and environmental resilience.

Purpose of the Study:

  • To highlight the critical role of microbiomes in achieving One Health goals.
  • To advocate for the integration of microbiome science into the One Health agenda.
  • To propose how microbiome science can enhance existing One Health strategies.

Main Methods:

  • This is a perspective piece, outlining the importance of microbiome science.
  • It analyzes how microbiome functions align with One Health objectives.
  • It suggests integrating microbiome considerations into policy and action plans.

Main Results:

  • Microbiome science offers a root-cause approach to global health challenges, moving beyond symptom management.
  • Integrating microbiomes can lead to innovative solutions for zoonotic disease prevention and AMR mitigation.
  • Understanding microbiomes enhances food safety and environmental sustainability efforts.

Conclusions:

  • Integrating microbiomes into the One Health agenda is imperative for sustainable and proactive global health solutions.
  • Microbiome science provides a powerful lens for addressing complex, interconnected health issues.
  • A microbiome-inclusive One Health approach fosters cross-sectoral collaboration and long-term resilience.