Bibliometric and visualized analysis of the therapeutic application of suprachoroidal space from 2000 to 2024

To provide a bibliometric overview of the global research on the therapeutic applications of the suprachoroidal space (SCS) from 2000 to 2024.

Publications were retrieved from the Web of Science Core Collection using a defined search strategy. A total of 776 articles were analyzed for trends in publication volume, countries, institutions, authorship, journals, citations, and keywords. An analysis of top 10% highly cited publications was also conducted. Co-authorship, co-occurrence, and citation burst analyses were conducted using VOSviewer, bibliometrix (R), and CiteSpace.

Global publications on SCS therapy increased steadily, with a 575% growth. The United States led in output (n = 274, 35.3%) and international collaboration. Top institutions included the University of Melbourne, Bionics Institute, and Osaka University. Fujikado Takashi was the most prolific author (34 publications), while Prausnitz Mark R R had the highest citation impact (50 per article). Investigative Ophthalmology & Visual Science was the most active journal (n = 50; 2249 citations). Keyword analysis revealed three main clusters: (1) drug delivery, (2) glaucoma treatment, and (3) retinal prosthesis. Overlay map indicated that research foci have shift from implantation to injection, minimally invasive approach, and clinical trials. Burst keywords showed suprachoroidal drug delivery (including gene therapy, ranibizumab, and triamcinolone acetonide) was a rapidly evolving and promising field for innovation, which was confirmed by analysis of high-impact publications.

This study maps the global research landscape and emerging trends on the therapeutic applications of the SCS, underscores its translational nature, and fosters interdisciplinary collaboration in this evolving field.