Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amiodarone reduces plasma warfarin clearance in man.

A H Watt, M R Stephens, D C Buss

    British Journal of Clinical Pharmacology
    |December 1, 1985
    PubMed
    Summary

    Amiodarone significantly reduces warfarin clearance, increasing its effect. This drug interaction occurs without affecting warfarin

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A change in the trend in dosulepin usage following the introduction of a prescribing indicator but not after two national safety warnings.

    Journal of clinical pharmacy and therapeutics·2016
    Same author

    A comparative study of methyldopa and labetalol in the treatment of hypertension.

    British journal of clinical pharmacology·2015
    Same author

    Mean steady-state plasma concentrations of labetalol in patients undergoing antihypertensive therapy.

    British journal of clinical pharmacology·2015
    Same author

    A multicentre open trial of labetalol in New Zealand.

    British journal of clinical pharmacology·2015
    Same author

    Impact of anti-cancer drugs and other determinants on serum protein binding of morphine 6-glucuronide.

    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences·2012
    Same author

    Evidence of active transport involvement in morphine transport via MDCKII and MDCK-PGP cell lines.

    Research in pharmaceutical sciences·2011

    Area of Science:

    • Pharmacology
    • Cardiology
    • Drug Interactions

    Background:

    • Amiodarone is a widely used antiarrhythmic medication.
    • A known drug interaction involves amiodarone potentiating warfarin's anticoagulant effect.
    • The underlying mechanism for this amiodarone-warfarin interaction remains poorly understood.

    Purpose of the Study:

    • To investigate the mechanism behind the interaction between amiodarone and warfarin.
    • To determine how amiodarone affects warfarin's pharmacokinetics in patients.

    Main Methods:

    • Eight patients receiving both amiodarone and warfarin were studied.
    • Warfarin clearance and plasma protein binding were assessed.
    • Plasma amiodarone concentrations were measured.

    Main Results:

    • Amiodarone significantly reduced total plasma warfarin clearance.
    • No alteration in warfarin's binding to plasma proteins was observed.
    • Plasma amiodarone levels did not correlate with changes in warfarin clearance.

    Conclusions:

    • Amiodarone impairs warfarin elimination, leading to increased anticoagulant activity.
    • The interaction is not due to changes in warfarin's protein binding.
    • Reduced warfarin clearance is the primary mechanism for this significant drug interaction.

    Related Experiment Videos