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GLP-1 RAs and Cardiovascular and Kidney Outcomes by Body Mass Index in Type 2 Diabetes.

Tien-Hsing Chen1,2,3, En-Hao Hu4,2, Dong-Yi Chen5,2

  • 1Division of Cardiology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.

JAMA Network Open
|September 8, 2025
PubMed
Summary

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show BMI-dependent cardiovascular benefits in type 2 diabetes patients. These agents also provide consistent kidney protection, highlighting the importance of BMI stratification for treatment decisions.

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